PReS-FINAL-2144: Bone mineral status in patients with juvenile idiopathic arthritis after 12 months of treatment with etanercept
نویسندگان
چکیده
Methods In prospective study of 63 polyarticular JIA pts (46 F, 17 M), median age 15 yrs. Treated with ETN 0,4 mg/kg/2× week. BMD and bone mineral content (BMC) by dual xray absorptiometry on the lumbar spine (L2-L4) were assessed. For statistical analysis Z score and bmdvol were taken as well. ACR pedi 50 criteria (physician global assessment-PGA, parent’s/patient’s global assessment, No of joints with limited range of motion-LOM, No of joints with active arthritis, functional ability assessment using CHAQ-Serbian version and ESR) were done at the baseline and one year later.
منابع مشابه
Bone mineral density improvement after one year of treatment with etanercept in patients with juvenile idiopathic arthritis
After the first year of treatment we have noticed significant improvement of all ostedensitometric values. Mean value difference for BMD, compare to baseline was 7,1% (p < 0,001) for Z score 17,76% (p = 0,002), for BMC 13,13% (p < 0,001) and for BMDvol 5% (p < 0,001). Bone mineral status continued to increase during the second years of treatment as well (13 pts) (p < 0,001). Conclusion Our resu...
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Methods Samples were collected from 71 JIA patients (43 polyarthritis (12 RF positive), 18 extendend oligoarthritis, 3 persistent oligoarthritis, 1 enthesitis related arthritis, 6 psoriatic arthritis) included in the Dutch Arthritis and Biologics in Children (ABC) Register treated with etanercept. The patients were categorized into responders (acrpedi≥50) (n = 55) and non-responders (acrpedi≤50...
متن کاملPReS-FINAL-2142: Predictors of persistent remission following etanercept (ETN) withdrawal in patients with juvenile idiopathic arthritis (JIA)
Methods Retrospective data of polyarticular JIA patients who discontinued ETN due to clinical remission on therapy and had a follow-up period after ETN withdrawal of at least 12 months were collected, including: age, number and type of active joints at disease onset, sex, ANA status, disease duration before ETN start, number and type of active joints, ESR, and CRP at the time of ETN start, dura...
متن کاملPReS-FINAL-2093: Can clinical response within 12 weeks in JIA-etanercept receivers predict the future clinical remission?
Introduction Induction of inactive disease (ID) in Juvenile Idiopathic Arthritis (JIA) is the main target of all current regimes, as it will maintain physical ability and hinder disease associated-damage. Early predictive markers for the future achievement of ID in patients under expensive therapies are therefore urgently needed in the era of financial recession. Our previous published experien...
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